【多选题】
ENESTnd研究中,随访到第5年时,达希纳300mgBID和伊马替尼治疗组的患者中,累积达到MMR的患者的百分比是多少?
A. 55%、27%
B. 62%、40%
C. 76%、56%
D. 77%、60%
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答案
D
解析
暂无解析
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GIMEMA CML工作组数据,格列卫治疗CML-AP患者,()患者回复至慢性期。
A. 0.7
B. 0.85
C. 0.9
D. 0.96
【多选题】
GIMEMA CML工作组数据,格列卫治疗CML-AP患者,CHR持续率和CCyR持续率可达()。
A. 0.56
B. 0.81
C. 56%和81%
D. 81%和56%
【多选题】
GIMEMA CML工作组数据,格列卫治疗CML-AP患者的7年OS达()
A. 0.43
B. 0.3
C. 0.23
D. 0.17
【多选题】
ICH是指()
A. 欧洲药品管理局
B. 国际协调会议
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
Ph+CML慢性期患者因换用α晶型仿制品而导致的生存期下降缓型显示,格列卫换用α晶型仿制品治疗最差的情况下,患者质量调整生存年仅有()
A. 13.44年
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C. 9.57年
D. 5年
【多选题】
α晶型仿制品不仅稳定性差,还普遍存在()含量超标。
A. 遗传学毒性杂质
B. 活性成分
C. 选项1和2
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼()格列卫。
A. 就是
B. 不等于
C. 优于
D. 以上所有选项均错误
【多选题】
α晶型甲磺酸伊马替尼处于(),可能向β晶型转变。
A. 高能态
B. 低能态
C. 稳定态
D. 以上所有选项均错误
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α晶型结构不稳定,可向β晶型自发转换,其可导致药物肉眼可见的改变,如()。
A. 药片崩裂
B. 药液变色
C. 药液变浑浊
D. 以上所有选项
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α晶型吸水性强,吸水溶解游离出甲磺酸阴离子与结晶时残留的乙醇反应生成
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B. 甲磺酸乙酯
C. 选项1和2
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【多选题】
β晶型的吸水性明显比α晶型(),吸水性强可影响药物的稳定性。
A. 更低
B. 更高
C. 相同
D. 以上所有选项均错误
【多选题】
不同国家和地区仿制品注册标准(),如进行人体生物利用度和生物等效性试验,成分鉴定和杂质定性评价和严格遵守eGMP规定。
A. 基本相同
B. 存在很大差异
C. 存在较小差异
D. 以上所有选项均错误
【多选题】
除颜色、形态/多晶型和熔点外,受多晶型影响的特征有()
A. 溶解度和生物利用度
B. 吸水性和晶体硬度、密度
C. 多态形式之间的转变和化学稳定性
D. 以上所有选项
【多选题】
达希纳服药()小时后,药物达到峰浓度。
A. 1
B. 2
C. 3
D. 4
【多选题】
达希纳服药前()小时之内和服药后()小时之内避免进食。
A. 2,1
B. 1,2
C. 1,1
D. 2,2
【多选题】
达希纳一线治疗的剂量是()。
A. 300mg BID
B. 400mg BID
C. 300mg QD
D. 400mg QD
【多选题】
达希纳一线治疗的疗效经临床证实可持续至少()个月。
A. 20
B. 30
C. 50
D. 60
【多选题】
达希纳与BCR/ABL的结合力是伊马替尼的多少倍?
A. 5倍
B. 10倍
C. 20倍
D. 30倍
【多选题】
达希纳治疗患者的胸腔和心包积液发生率为()。
A. ≤5%
B. ≤1%
C. ≤10%
D. ≤15%
【多选题】
达希纳治疗开始前评估血脂情况,并在治疗开始后()个月、()个月时进行评估,以及在长期治疗期内至少每年评估一次。
A. 3,6
B. 1,2
C. 1,3
D. 2,3
【多选题】
达希纳治疗时,要密切监测QTc,包括治疗开始前、治疗()天后以及根据临床指征进行ECG检查。
A. 3
B. 4
C. 5
D. 7
【多选题】
低标准仿制品药物均匀度差,可导致()
A. 患者每次服药都可能服用的是不同剂量
B. 疗效可能降低
C. 毒性反应风险或治疗耐药风险增加
D. 以上多有选项
【多选题】
低标准仿制品有效成分含量过高或过低,可导致()
A. 毒性增加
B. 无效治疗
C. 毒性增加或无效治疗
D. 治疗耐药
【多选题】
电子显微镜下—α晶型和β晶型()
A. 存在差异
B. 不存在差异
C. 没有差异
D. 以上所有选项均错误
【多选题】
X-射线粉末衍射所示—α晶型和β晶型()。
A. 存在差异
B. 不存在差异
C. 没有差异
D. 以上所有选项均错误
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对伊马替尼仿制品库中的106种药品进行遗传毒性杂质检测,()格列卫仿制品遗传毒性杂质日暴露量远超过EMA规定的限值。
A. 绝大多数
B. 少部分
C. 所有
D. 几乎没有一种
【多选题】
对伊马替尼仿制品库中的106种药品进行遗传毒性杂质检测,有超过()遗传毒性杂质不符合格列卫标准。
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B. 0.7
C. 0.8
D. 0.9
【多选题】
对于不能吞下达希纳胶囊的患者,可以把胶囊的内容物与一茶匙的()混合在一起,混合后应立即服用。
A. 菠萝酱
B. 香蕉酱
C. 苹果酱
D. 沙拉酱
【多选题】
多晶型影响药物的生物利用度,包括()
A. 在血液中浓度的变化可能会影响治疗效果、毒性
B. 在血液中浓度的变化可能会影响安全性和耐受性
C. 耐受性的变化可引起更多的休药期,这样可能会导致治疗的失败
D. 以上所有选项
【多选题】
多晶型之间的转变可能影响药物的()
A. 产物的均一度
B. 多晶体组成的不同可引起保质期的变化
C. 存储过程中的老化降解
D. 以上所有选项
【多选题】
分子学监测采用外周血,检测结果小时内获得。
A. 24
B. 36
C. 48
D. 72
【多选题】
高水平的已知遗传毒性杂质可能()癌症的发生风险
A. 增加
B. 降低
C. 不影响
D. 以上所有选项均错误
【多选题】
格列卫拥有(),质量稳定可靠
A. α晶型专利
B. β晶型专利
C. γ晶体专利
D. 以上所有选项
【多选题】
根据2013中国CML诊疗指南,400mg/d伊马替尼治疗慢性期CML时,3个月时最佳反应是( )?
A. 达到CHR基础上至少达到mCyR(Ph+细胞≤65%)
B. BCR-ABL(IS)≤10%
C. 以上均正确
D. 以上均不正确
【多选题】
根据ELN指南,()属于治疗失败?
A. 达到CHR基础上至少达到PCyR(Ph+细胞≤35%)
B. 6个月时没有达到CCyR
C. 12个月时没有达到MMR
D. 在任何时间失去曾经获得的CCyR
【多选题】
根据NCCN2011指南,CML-CP治疗获得主要分子学反应(MMR)中BCR-ABL转录本较(本中心)治疗前下降( )。
A. 定量PCR测不到BCR-ABL转录本
B. ≥3log
C. ≥2log
D. ≥1log
【多选题】
根据国际标准基线,2013ELN指南规定患者应该在什么时间达到MMR?
A. 6个月
B. 12个月
C. 18个月
D. 24个月
【多选题】
根据国际标准基线,2013ELN指南规定患者在6个月时应该达到( )?
A. CHR
B. PCyR
C. CCyR
D. MMR
【多选题】
关于ENESTnd和ENESTchina研究,以下哪个说法是错误的?
A. ENESTnd是3臂试验,ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTchina中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
关于药物应选择的晶型描述正确的是:
A. 热力学稳定性最佳、潜在转变成其他晶型的可能性最小
B. 热力学稳定性最佳
C. 潜在转变成其他晶型的可能性最小
D. 以上所有选项均错误
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【单选题】
When an administrator initiates a device wipe command from the ISE, what is the immediate effect?___
A. It requests the administrator to choose between erasing all device data or only managed corporate data.
B. It requests the administrator to enter the device pin or password before proceeding with the operation
C. It notifies the device user and proceeds with the erase operation
D. It immediately erases all data on the device
【单选题】
What is a valid implicit permit rule for traffic that is traversing the ASa firewall?___
A. ARPs in both directions are permitted in transparent mode only
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C. Unicast IPv6 traffic from a higher security interface to a lower security interface is permitted in transparent mode only.
D. Only BPDUs from a higher security interface to a lower secur ity interface are permitted in transparent mode.
E. Only BPDUs from a higher security interface to a lower secur ity interface are permitted in routed mode
【单选题】
A specific URL has been identified as containing malware. What action can you take to block users from accidentally visiting the URl and becoming infected with malware ?___
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【单选题】
How does PEAP protect the EAP exchange ?___
A. It encrypts the exchange using the server certificate
B. It encrypts the exchange using the client certificate
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D. It validates the client-supplied certificate,and then encrypts the excha nge using the server certificate
【单选题】
Which feature of the Cisco Email Security Appliance can mitigate the impact of snowshoe spam and sophisticated phishing attacks?___
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【单选题】
Refer to the exhibit【nat (inside,outside)dunamic interface】 Which translation technique does this configuration result in?___
A. DynamIc PAT
B. Dynamic NAT
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【单选题】
Refer to the exhibit which are repre sents the data center?___
A. A
B. B
C. C
D. D
【单选题】
While trouble shooting site-to-site VPN, you issued the show crypto isakmp sa command. What does the given output show?___
A. IKE Phase 1 main mode was created on 10.1.1.5, but it failed to negotiate with 10.10 10.2
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C. IKE Phase 1 aggressive mode was created on 10.1.1.5, but it failed to negotiate with
【单选题】
Refer to the exhibit All ports on switch 1 have a primary vLan of 300 Which devices can host 1 reach?___
A. host 2
B. server
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Which option is the cloud-based security service from Cisco the provides URL filtering, web browsing content security, and roaming user protection?___
A. Cloud Web service
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How can you detect a false negative on an IPS?___
A. View the alert on the ips
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what improvement does EAP-FASTv2 provide over EAP-FAST? ___
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Which user authentication method is used when users login to the Clientless SSLVPN portal using https://209.165.201.2/test?___
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Which statement about the communication between interfaces on the same security level is true?___
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A. ESA
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which iPS mode is less secure than other options but allows optimal network through put ?___
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Refer to the exhibit for which reason is the tunnel unable to pass traffic___
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Which type of attack can exploit design flaws in the implementation of an application without___
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How can you protect CDP from reconnaissance attacks?___
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C.
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Which type of attack can exploit design flaws in the implementation of an application without ?___
A. DHCP starvation attacks
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hich description of the nonsecret numbers that are used to start a Diffie- Hellman exchange is ture?___
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Which two characteristics of an application layer firewall are true?___
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【多选题】
Which two devices are components of the BYOD architectural framework?___
A. Nexus 7010 switch
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【多选题】
Which two actions can a zone based firewall take when looking at traffic? ___
A. forward
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【多选题】
n which two situations should you use in-band management?___
A. when management applications need concurrent access to the device
B. when you require administrator access from multiple locations
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D. when you require ROMMON access
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【多选题】
What are two ways to prevent eavesdropping when you perform device management tasks?___
A. Use an SSH connection.
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【多选题】
Which two features are commonly used CoPP and CPPr to protect the control plane? ___
A. QoS
B. traffic classification
C. access lists
D. policy maps
E. class maps
F. Cisco Express Forwarding
【多选题】
Which four tunne ling prot ocols are enabled in the Dfit GrpPolicy group policy ?___
A. Clientless SSL VPN
B. SSL VPN Client
C. PPTP
D. L2TP/IPsec
E. IPsec IKEv1
F. IPsec IKEv2
【多选题】
Which two statements regarding the aSA VPN configurations are correct?___
A. The asa has a certificate issued by an external certificate authority associated to the ASDM TrustPoint1
B. The Default WEBVPNGroup Connection Profile is using the aaa with RADIUS server method
C. The Inside-srvbook mark references the https://192.168.1.2url
D. Only Clientless SSL VPN access is allowed with the Sales group policy
E. Any Connect, IPSec IKEv1, and IPSec IKEv2 VPN access is enabled on the outside interface
F. The Inside -SRV bookmark has not been applied to the Sales group policy
【多选题】
Which three ESP fields can be encrypted during transmission?___
A. Security Parameter Index
B. Sequence Number
C. MAC Address
D. Padding
E. Pad length
F. Next Header