【单选题】
2)Chemists often start a combinatorial synthesis by attaching the first set of building blocks_____ to microscopic beads made of polystyrene.___
A. solid
B. inert
C. soft
D. active
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答案
B
解析
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相关试题
【单选题】
3）The chemical reactions required to link compounds to the beads and later to detach them____ to the synthesis proces.___
A. induce complications
B. make easy
C. introduce complications
D. introduce easy
【单选题】
4)In a parallel synthesis, all the products are_____ separately in their own reaction vessels.___
A. combined
B. assembled
C. joined
D. assorted
【单选题】
(5)In many laboratories today, robots assist with the routine work of parallel synthesis, such as small___ amounts of reactive molecules into the appropriate wells.___
A. sending
B. transporting
C. delivering
D. giving
【单选题】
(6)Scientists can pull out from the mixture the beads that bear biologically active molecules and then,using sensitive detection techniques,___ the molecular makeup of the compound attached.___
A. determine
B. make sure
C. find
D. search
【单选题】
(7)Most pharmaceutical companies today continue to___ parallel synthesis. Which of the following is not appropriate to be filled in the blank?___
A. count in
B. count on
C. depend on
D. rely on
【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
A. 对
B. 错
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
A. 对
B. 错
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
A. 对
B. 错
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
A. 对
B. 错
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
A. 对
B. 错
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
A. 对
B. 错
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
A. 对
B. 错
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
A. 对
B. 错
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
A. 对
B. 错
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
A. 对
B. 错
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
A. 对
B. 错
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
A. 对
B. 错
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
A. 对
B. 错
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
A. 对
B. 错
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
A. 对
B. 错
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
A. 对
B. 错
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
A. 对
B. 错
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
A. 对
B. 错
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
A. 对
B. 错
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
A. 对
B. 错
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
A. 对
B. 错
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
A. 对
B. 错
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【多选题】
井下作业施工前，作业队应做的工作有___。
A. 向全队职工进行地质、工程和井下等方面的技术措施交底
B. 并明确班组各岗位分工
C. 对施工现场的井控装备、配备的防喷工具进行检查，使之处于完好状态
D. 按设计要求备足修井液
【多选题】
洗井施工中为防止井喷的发生应做的工作有___。
A. 按施工设计的管柱结构要求，将洗井管柱下至预定深度
B. 地面管线试压至设计施工泵压的1．5倍，经5min后不刺不漏为合格
C. 洗井时要注意观察泵压变化，泵压不能超过油层漏失压力
D. 严重漏失井采用有效堵漏措施后，再进行洗井施工
【多选题】
起下管柱作业应按以下要求执行___。
A. 在起下封隔器等大直径工具时，应控制起下钻速度，防止产生抽汲或压力激动
B. 在起管柱过程中，应及时向井内补灌压井液，保持液柱压力平衡
C. 起下管柱作业出现溢流时，可以观察情况，根据情况决定什么时候关井
D. 起下管柱过程中，要有防止井内管柱顶出的措施，以免增加井喷处理难度
【多选题】
施工设计的井控要求中，制定具体的预防和应急措施，应包括但不限于___、防喷器的规格、组合及示意图、四种作业工况时，应有具体的井控预防措施等内容。
A. 压井液要求
B. 井架高度
C. 井控装置的现场安装、调试与试压要求等
D. 发生溢流时的关井方法的确定
【多选题】
井下作业的地质设计、工程设计、施工设计中必须有相应的井控要求或明确的井控设计，主要包括：满足井控安全的各种资料数据，___、符合部颁标准的井控装备系统、有关法规及应急计划等。
A. 施工前准备工作
B. 合理的井场布置
C. 适合地层特性的修井液类型
D. 合理的修井液密度
【多选题】
对于施工井场布置的相关要求，以下说法正确的是___。
A. 作业井施工现场的电路布置、设备安装等都要确保作业正常施工
B. 工具房、值班房、爬犁等摆放整齐距井口和易燃物品的距离不得小于25m
C. 上岗人员懂防火知识，可以不用定期检查保养消防器材
D. 照明灯采用防爆低压安全探照灯或防爆探照灯，距井口不少于10m
【多选题】
起下管柱操作时应做好的防喷措施有___。
A. 防喷器、远程控制台和井控管汇的安装、试压要符合相关规定
B. 中途停工必须装好井口或关闭防喷装置
C. 起下作业前，在井口附近应准备好简易防喷工具或防喷单根
D. 允许边喷边作业，起完管柱应立即关闭防喷装置
【多选题】
井喷（井喷失控）应急处置内容包括：___。
A. 关防喷器控制井口，防止事态扩大，根据实际关井压力组织压井
B. 组织有关人员检测有无有毒有害气体，划分安全区域，设立警戒线
C. 准备好相应的正压式空气呼吸器
D. 必要时通知周边居民、厂矿、学校人员做好疏散工作
【多选题】
带压作业过程中必须做到：___。
A. 井口装置、井下管柱结构及地面设施必须具备不压井、不放喷及应变抢救作业的各种条件
B. 作业施工前应接好放喷平衡管线
C. 不压井井口控制装置要求动作灵活、密封性能好、连接牢固、试压合格，并有性能可靠的安全卡瓦
D. 起下管柱过程中，随时观察井口压力及管柱变化。当超过安全工作压力或发现管柱自动上顶时，应及时采取加压及其他有效措施
【多选题】
带压作业在起下油管过程中，如环形防喷器不能有效密封，出现刺漏时___。
A. 视井内情况可以继续作业
B. 抢装旋塞阀，关闭旋塞阀
C. 关闭安全防喷器半封闸板，并手动锁紧
D. 及时更换环形防喷器胶芯
【多选题】
冲砂施工中应做好的防喷工作有___。
A. 冲砂作业要使用符合设计要求的压井液进行施工
B. 按工程设计安装好防喷器，防喷器的试压
C. 当探砂面管柱不具备冲砂条件时，可以用探砂面管柱直接冲砂
D. 施工中井口应坐好自封封井器和防喷器
【多选题】
打捞作业前，要了解施工井生产情况，包括产液量、含水、油气比、___等资料，了解施工井与周围注水井的连通情况以及气井及其相关参数等。
A. 油压
B. 套压
C. 静压
D. 目前地层压力系数
