【多选题】
如果临床需要,达希纳可与造血生长因子或其他联用,例如( )。
A. EPO
B. G-CSF
C. 羟基脲
D. 阿那格雷
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答案
ABCD
解析
暂无解析
相关试题
【多选题】
如果出现血液学毒性( ),应暂停达希纳的使用。
A. 加速期:ANC<0.5×109/升或血小板<10×109/升
B. 慢性期:ANC<1.0×109/升或血小板<50×109/升)
C. 加速期:ANC<1×109/升或血小板<10×109/升
D. 慢性期:ANC<10×109/升或血小板<50×109/升
【多选题】
评价二代TKI做为新诊断CML-CP患者一线治疗疗效和安全性研究的临床试验包括( )。
A. ENESTnd
B. ENESTchina
C. DASISION
D. ENESTcmr
【多选题】
哪些属于血液学不良反应( )。
A. 血小板减少症
B. 中性粒细胞减少症
C. 腹泻
D. 贫血
【多选题】
哪些属于非血液学不良反应( )。
A. 中性粒细胞减少症
B. 胃肠道异常
C. 皮疹
D. 肌痛
【多选题】
关于ENESTnd和ENESTchina 研究, 以下说法正确有( )。
A. ENESTnd是3臂试验,ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
C. ENESTnd中入组患者的中位年龄更大
D. ENESTnd中入组更多中高危患者
【多选题】
骨髓抑制一般是可逆的,可以通过暂时停达希纳或降低剂量来控制。
A. 是
B. 否
C. QQ
D. PP
【多选题】
根据ELN指南,达到满意疗效的Bcr-Abl转录本的水平是( )。
A. TKI 治疗3个月,Bcr-Abl : ≤ 10%
B. TKI 治疗6个月,Bcr-Abl : ≤ 1%
C. TKI 治疗12个月,Bcr-Abl :≤0.1%
D. 所有选项均不正确
【多选题】
服用达希纳时,应注意的事项有( )。
A. 电解质异常
B. 肝功能异常
C. 血清脂肪酶升高
D. QT间期延长
【多选题】
服用达希纳时,如果出现有显著临床意义的中度或严重的非血液学毒性,应该暂停服药。
A. 是
B. 否
C. QQ
D. PP
【多选题】
服用达希纳时,任何时候都应该避免进食( )。
A. 葡萄柚汁
B. 苹果汁
C. 已知的有抑制CYP3A4作用的食物
D. 香蕉汁
【多选题】
达希纳能够抑制( )激酶的自磷酸化。
A. Bcr-Abl(20-60nM)
B. PDGFR(69nM)
C. Src
D. c-Kit(210nM)
【多选题】
达希纳胶囊服用时,可以咀嚼或吮吸,可以打开胶囊。
A. 是
B. 否
C. QQ
D. PP
【多选题】
达希纳含有乳糖,所以对于( )的患者,不推荐使用。
A. 半乳糖不耐受症
B. 严重的乳糖酶缺陷
C. 葡萄糖-半乳糖吸收障碍
D. 所有选项均不正确
【多选题】
达希纳服用时,如果错过给药,患者不得另外补充剂量,而是按照处方服用下一次剂量。
A. 是
B. 否
C. QQ
D. PP
【多选题】
达希纳不可以与羟基脲或阿那格雷联用。
A. 是
B. 否
C. QQ
D. PP
【多选题】
伴有( )的患者禁用达希纳。
A. 低钾血症
B. 低镁血症
C. 长QT综合征
D. 所有选项均不正确
【多选题】
TKI治疗均的CV风险管理中,属于可更改的因素有( )。
A. 高血压
B. 吸烟
C. 糖尿病
D. 饮食
【多选题】
TKI治疗均的CV风险管理中,属于不可更改的因素有( )。
A. 年龄
B. 性别
C. 家族史
D. 血脂
【多选题】
ENESTnd研究中的分组有( )。
A. 达希纳300mg BID
B. 达希纳400mg BID
C. 伊马替尼400mg QD
D. 伊马替尼400mg BID
【多选题】
ENESTnd研究中,在5年随访中,所有时间点达希纳组MMR的比例始终高于伊马替尼组。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd研究中,与伊马替尼相比,达希纳一线治疗组疾病进展至AP/BC显著更少。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd研究中,排除( )类型的患者。
A. 临床显著的心动过缓
B. 近期的心肌梗死
C. 充血性心脏衰竭
D. 不稳定型心绞痛
【多选题】
ENESTnd研究中,从第一年至第五年的随访中,达希纳和伊马替尼组累积的MR4.5相差的比例保持完全不变。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd标志性分析中,3个月时获得BCR-ABLIS≤10%与60个月时更佳的OS无关
A. 是
B. 否
C. QQ
D. PP
【多选题】
在TIDEL-II研究中,服用伊马替尼二线治疗的患者在3个月时没有达到EMR的比例为
A. 0.08
B. 0.09
C. 0.12
D. 0.15
【多选题】
在ENESTnd研究中,在伊马替尼400mg每天治疗失败后将剂量增加至600或800 mg每天不会导致超过一半的患者反应改善。
A. 是
B. 否
C. QQ
D. PP
【多选题】
在ENESTnd研究所有风险组中,伊马替尼治疗的EMR失败率比达希纳高3-4倍。
A. 是
B. 否
C. QQ
D. PP
【多选题】
在ENESTnd或DASISION研究中,5年随访时,伊马替尼二线治疗组获得MR4.5的中位时间均未达到。
A. 是
B. 否
C. QQ
D. PP
【多选题】
"与竞品达沙替尼相比,达希纳精准强效抑制BCR-ABL
A. 是
B. 否
C. QQ
D. PP
【多选题】
与竞品达沙替尼相比,达希纳非血液学不良反应交叉不耐受发生率高?
A. 是
B. 否
C. QQ
D. PP
【多选题】
以下关于DASISION研究的描述,正确的是( )。
A. DASISION试验的研究终点是CCyR,而不是MMR
B. DASISION试验中,达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中,达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
IRIS研究中,伊马替尼治疗12个月内的MMR率为
A. 0.61
B. 0.39
C. 0.28
D. 0.38
【多选题】
IRIS研究随访10年, 32% 伊马替尼治疗患者由于不满意治疗反应中断治疗,>10%由于不良事件。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENRICH研究中,接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后,达到MR4.5的患者比例为
A. 0.19
B. 0.23
C. 0.42
D. 0.44
【多选题】
ENRICH研究中,接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后,达到MMR的患者比例为
A. 0.69
B. 0.78
C. 0.88
D. 0.99
【多选题】
ENESTnd研究中在伊马替尼治疗12个月内的MMR率为27%。
A. 是
B. 否
C. QQ
D. PP
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
DASISON 研究中,达沙替尼胸腔积液的复发率是( )。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
DASISION研究的终点是( )。
A. 6个月内,证实获得的CCyR
B. 12个月内,证实获得的CCyR
C. 6个月内,证实获得的MMR
D. 12个月内,证实获得的MMR
【多选题】
DASISION 研究4年随访中,22%的达沙替尼治疗患者中经常报告的不良事件是()。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
推荐试题
【单选题】
The following except are guaranteed in the Bill of Rights.
A. A. freedom of religion
B. B. the right to get into people’s house by police
C. C. freedom of speech and of press
D. D. the right to own one’s weapon if one wishes
【单选题】
The Bill of Rights .
A. A. defines the rights of Congress and the rights of the President
B. B. guarantees citizens of the United States specific individual rights and freedoms
C. C. is part of the Declaration of Independence
D. D. has no relationship with the Constitution
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The Constitution of the United States .
A. A. gives the most power to Congress
B. B. gives the most power to the President
C. C. tries to give each branch enough power to balance the others
D. D. gives the most power to the Supreme Court
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The U. S. Constitution came into effect in .
A. A. 1787
B. B. 1789
C. C. 1791
D. D. 1793
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The Vietnam War was a long-time suffering for Americans, and it continued throughout the terms of Presidents .
A. A. Johnson, Nixon and Ford
B. B. Truman, Eisenhower and Kennedy
C. C. Kennedy, Johnson and Nixon
D. D. Eisenhower, Kennedy and Johnson
【单选题】
President applied New Deal to deal with the problems of the Great Depression.
A. A. Wilson
B. B. Truman
C. C. Roosevelt
D. D. Kennedy
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The policy of the United States was at the beginning of the two world wars.
A. A. neutrality
B. B. full involvement
C. C. partial involvement
D. D. appeasement
【单选题】
Abraham Lincoln issued to grant freedom to all slaves.
A. A. Declaration of Independence
B. B. Constitution
C. C. Emancipation Proclamation
D. D. Bill of Rights
【单选题】
In May 1775, was held in Philadelphia and began to assume the functions of a national government.
A. A. the First Continental Congress
B. B. the Second Continental Congress
C. C. the Boston Tea Party
D. D. the Congress of Confederation
【单选题】
The first shots of the American dependence were fired in .
A. A. Concord
B. B. Lexington
C. C. Philadelphia
D. D. Boston
【单选题】
“No taxation without representation” was the rallying slogan of .
A. A. the settlers of Virginia
B. B. the people of Pennsylvania
C. C. the colonists in New England
D. D. the people of the 13 colonies
【单选题】
The Seven Years’ War occurred between the .
A. A. French and American Indians
B. B. French and Spaniards
C. C. French and British
D. D. British and American Indians
【单选题】
Pilgrim Fathers are a group of who came to America to avoid persecution in England.
A. A. Protestants
B. B. Puritans
C. C. Catholics
D. D. Christians
【单选题】
The first successful English colony in North America was founded at in .
A. A. Jamestown, Louisiana
B. B. Boston, Massachusetts
C. C. Jamestown, Virginia
D. D. Plymouth, Georgia
【单选题】
The characteristic of dominant American culture is .
A. A. English-speaking, northern European, Roman Catholic and middle-class
B. B. English-speaking, western European, Roman Catholic and upper-class
C. C. English-speaking, northern European, Protestant and upper-class
D. D. English-speaking, western European, Protestant and middle-class
【单选题】
The ImmiWar of Ingrants Act of 1924 restricted the further immigration into the United States, particularly from .
A. A. Europe
B. B. Asia
C. C. Africa
D. D. South America
【单选题】
The largest minority in the United States is the .
A. A. Pacific Islanders
B. B. Blacks
C. C. Native Americans
D. D. Asians
【单选题】
The native Alaskan population includes the following except the .
A. A. Indians
B. B. Eskimos
C. C. Aleuts
D. D. Blacks
【单选题】
is located on the U. S. –Canadian border between Lake Erie and Lake Ontario.
A. A. Yellowstone National Park
B. B. The Grand Canyon
C. C. Niagara Falls
D. D. The Great Salt Lake
【单选题】
Some of the world famous universities like Harvard, Yale and MIT are located .
A. A. in the South
B. B. along the Pacific Coast
C. C. in New England
D. D. in the Midwest
【单选题】
The largest river in the U. S. is .
A. A. the Missouri River
B. B. the Mississippi River
C. C. the Ohio River
D. D. the Colorado River
【单选题】
The U. S. lies in North America, with Canada to the north, Mexico to the south, the Atlantic to its and the Pacific to its .
A. A. northern, east, west
B. B. central, east, west
C. C. southern, west, east
D. D. western, east, west
【单选题】
The state of is the largest in area of all the states.
A. A. Alaska
B. B. Hawaii
C. C. Texas
D. D. Florid
【单选题】
The United States has states on the continent.
A. A. 50
B. B. 49
C. C. 48
D. D. 35
【单选题】
Waiting for Godot is written by .
A. A. Samuel Beckett
B. B. George Orwell
C. C. William Golding
D. D. D. H. Lawrence
【单选题】
Of the following writers, is NOT a Nobel Prize winner.
A. A. Samuel Beckett
B. B. James Joyce
C. C. William Golding
D. D. V. S. Naipaul
【单选题】
Of the following statements, is NOT correct about Virginia Woolf.
A. A. She was a central figure of the “Bloomsbury Group”.
B. B. She experimented with stream of consciousness.
C. C. She was an influential feminist.
D. D. Her masterpiece was The Rainbow.
【单选题】
Of the following books, was NOT written by Thomas Hardy.
A. A. Jude the Obscure
B. B. Tess of the D’Urbervilles
C. C. Adam Bede
D. D. The Return of the Native
【单选题】
is NOT included in the modernist group.
A. A. Oscar Wild
B. B. Virginia Woolf
C. C. William Butler Yeats
D. D. T. S. Eliot
【单选题】
Of the following statements, is NOT correct in terms of Neo-Romanticism.
A. A. It prevailed at the end of the 19th century.
B. B. The writers were dissatisfied with the social reality.
C. C. The writers believed in “Art for Art’s Sake”.
D. D. Treasure Island was a representative work.
【单选题】
is a representative of English Critical Realism at the turn of the 19th century.
A. A. Robert Louis Stevenson
B. B. John Milton
C. Joseph Conrad
D. D. Thomas Hardy
【单选题】
Of Dickens’ novels, is considered autobiographical.
A. A. A Tale of Two Cities
B. B. David Copperfield
C. C. Oliver Twist
D. D. Great Expectations
【单选题】
is viewed as Romantic poetry’s “Declaration of Independence.”
A. A. “I Wondered Lonely as a Cloud”
B. B. Don Juan
C. C. “Preface to Lyrical Ballads”
D. D. Prometheus Unbound
【单选题】
The most significant achievement of the English Renaissance is .
A. A. poetry
B. B. drama
C. C. novel
D. D. pamphlet
【单选题】
The following Christmas traditions are particularly British except .
A. A. Trooping the Color
B. B. Queen’s Christmas message
C. C. Boxing Day
D. D. Christmas pantomime
【单选题】
Of the following, is NOT a common feature of all the British holidays.
A. A. families getting together
B. B. friends exchanging good wishes
C. C. friends enjoying each other’s company
D. D. families traveling overseas
【单选题】
is Britain’s top pay television provider.
A. A. BSB
B. B. SkyTV
C. C. BBC
D. D. BSkyB
【单选题】
Life on Earth is a kind of program produced by the BBC and is popular among 500 million viewers worldwide.
A. A. feature
B. B. drama
C. C. documentary
D. D. soap opera
【单选题】
Among Britain’s quality press, the following newspapers are regarded as the “Big Three” with the exception of .
A. A. The Times
B. B. The Guardian
C. C. The Observer
D. D. The Daily Telegraph
【单选题】
To be admitted to the Open University, one need .
A. A. some educational qualifications
B. B. no educational qualifications
C. C. General Certificate of Education-Advanced
D. D. General National Vocational Qualifications