【多选题】
如果临床需要,达希纳可与造血生长因子或其他联用,例如( )。
A. EPO
B. G-CSF
C. 羟基脲
D. 阿那格雷
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答案
ABCD
解析
暂无解析
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如果出现血液学毒性( ),应暂停达希纳的使用。
A. 加速期:ANC<0.5×109/升或血小板<10×109/升
B. 慢性期:ANC<1.0×109/升或血小板<50×109/升)
C. 加速期:ANC<1×109/升或血小板<10×109/升
D. 慢性期:ANC<10×109/升或血小板<50×109/升
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评价二代TKI做为新诊断CML-CP患者一线治疗疗效和安全性研究的临床试验包括( )。
A. ENESTnd
B. ENESTchina
C. DASISION
D. ENESTcmr
【多选题】
关于ENESTnd和ENESTchina 研究, 以下说法正确有( )。
A. ENESTnd是3臂试验,ENESTchina是2臂试验
B. 两个试验的研究终点基本相同
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以下关于DASISION研究的描述,正确的是( )。
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B. DASISION试验中,达沙替尼组与伊马替尼组获得MR4.5 的组间差异逐渐拉大
C. DASISION试验中,达沙替尼组并未显示比伊马替尼组显著降低疾病进展的风险
D. 反复发作的胸腔积液是多发的不良反应
【多选题】
ENRICH研究中,接受伊马替尼治疗出现低级别慢性AEs的患者换用达希纳12个月后,达到MR4.5的患者比例为
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【多选题】
DASISION研究的终点是( )。
A. 6个月内,证实获得的CCyR
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